Esketamine nasal spray is a regulated and evidence-informed treatment option for adults diagnosed with treatment-resistant depression. For those who have not found relief through standard antidepressant medications, esketamine may provide a new path toward managing symptoms and improving overall well-being. At SNBCare, a licensed behavioral health provider serving adults located in Massachusetts and Rhode Island, some clinicians are certified to offer REMS-compliant Spravato® (esketamine) nasal spray under careful supervision and clinical evaluation.
Understanding Esketamine Nasal Spray
Esketamine, the active ingredient in Spravato®, is derived from ketamine and works differently from traditional antidepressants. While most antidepressants target serotonin or norepinephrine, esketamine acts on the glutamate system, a pathway involved in mood regulation and neural communication. This difference in mechanism may help some adults experience faster symptom relief when other treatments haven’t worked effectively.
It’s important to note that esketamine nasal spray is only approved for adults with treatment-resistant depression and is not a first-line treatment. All patients must undergo a comprehensive psychiatric evaluation before being considered eligible.
How the Treatment Works
Esketamine nasal spray is a prescription only medication that must be administered in a certified medical office under supervision. It cannot be taken home or prescribed for self-use. At SNBCare, the process includes:
- Comprehensive Evaluation: A licensed behavioral health provider reviews your mental health history, medications, and treatment goals.
- In-Office Administration: The patient self-administers the nasal spray in the office, guided by trained staff.
- Observation Period: Patients remain in a calm, monitored environment for approximately two hours after administration for observation and safety.
- Follow-Up and Adjustment: Providers review the patient’s response, monitor side effects, and adjust the treatment plan if needed.
Esketamine nasal spray is often used alongside an oral antidepressant, as the combination may enhance effectiveness for some individuals.
Benefits and Safety
Some patients report experiencing improved mood, energy, and concentration after beginning esketamine treatment. However, results vary by individual, and no treatment guarantees universal effectiveness.
Potential benefits include:
- A new option for adults with treatment-resistant depression
- Evidence suggesting faster onset of symptom improvement
- Treatment provided in a controlled, supportive environment
Possible side effects may include:
- Dizziness or dissociation
- Temporary increases in blood pressure
- Nausea or mild sedation
Because of these effects, patients must arrange transportation home after each appointment and avoid driving until the following day.
Esketamine as Part of a Comprehensive Care Plan
Esketamine nasal spray works best when integrated into a comprehensive treatment plan designed by licensed behavioral health professionals. At SNBCare, care plans may include:
- Medication management for depression and anxiety
- Individual therapy sessions to build coping skills and resilience
- Ongoing psychiatric follow-up to monitor safety and progress
- Lifestyle and stress management support to encourage long-term wellness
By combining therapeutic, pharmacological, and behavioral approaches, SNBCare supports adults in creating sustainable, evidence-based recovery plans.
Who May Be Eligible for Esketamine Treatment
Adults may be considered for esketamine nasal spray treatment if they have:
- Tried at least two antidepressant medications without sufficient improvement
- Received a diagnosis of treatment-resistant depression from a licensed provider
- No contraindications based on medical history or current medication use
Eligibility is determined solely through clinical evaluation by a certified prescriber, ensuring each recommendation is appropriate and medically justified.
Why Choose SNBCare for Esketamine Nasal Spray
SNBCare is an established outpatient behavioral health clinic offering in-person and telemedicine psychiatric care for adults. Our offices in Massachusetts and Rhode Island provide access to compassionate, licensed professionals dedicated to ethical and evidence-informed care. Esketamine nasal spray treatment is currently administered at our Natick, Massachusetts office, where patients receive care in a safe, comfortable, and clinically supervised environment.
Our commitment includes:
- Safe, regulated administration of REMS-compliant Spravato® (esketamine) nasal spray
- HIPAA-compliant communication and medical record handling
- Compassionate, judgment-free treatment in a professional environment
- Coordinated care between prescribers, therapists, and behavioral health providers
SNBCare’s mission is to deliver individualized mental health care that respects each patient’s needs, goals, and safety at every step of treatment.
Taking the First Step Toward Support
For adults who continue to experience depression despite multiple treatment attempts, esketamine nasal spray may represent an alternative pathway to healing. If you believe this treatment might be right for you, our care coordination team can help schedule an evaluation with a licensed clinician to discuss eligibility, safety, and next steps.
At SNBCare, we believe that seeking help is an act of strength. Our providers are here to offer guidance, compassion, and professional care to help you move toward a more balanced and hopeful future.
SNBCare Service Note
SNBCare offers psychiatric and behavioral health services, including REMS-compliant Spravato® (esketamine) nasal spray treatment for eligible adults diagnosed with treatment-resistant depression. This treatment is available in-office only and not via telehealth. SNBCare serves adults who are physically located in Massachusetts or Rhode Island during their appointment. All services depend on provider availability and clinical appropriateness.
Medical Disclaimer
This content is for informational and promotional purposes only and is sponsored by SNBCare, a licensed behavioral health provider in Massachusetts and Rhode Island. It is not intended to replace professional medical advice, diagnosis, or treatment. Always seek the advice of your healthcare provider before beginning or modifying any treatment.